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Jan 062023
 

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Descriptions: infiniSee is a virtual screening platform. Based on similarity, it finds molecules of interest in chemical spaces of (almost) infinite size. Given a template or query molecule, infiniSee returns similar molecules from these chemical spaces — or from screening libraries.
With infiniSee you can finally compare apples and oranges. The underlying concept of infiniSee is strikingly easy: Instead of searching already “assembled” molecules, we instead perform a combinatorial build-up of compounds from “fragments”. Sources of fragments can be either combinatorial libraries or any fragment-generating procedure. infiniSee opens the possibility to screen billions of compounds through its similarity search technology by navigating vast Chemical Spaces and searching for distant neighbors of a query molecule. Results will be delivered within typically less than a minute on a standard laptop. Optionally, you can define fuzzy pharmacophores to increase the diversity of scaffolds or request important molecular structures to be present in the hits.
The ingenious twist of infiniSee is the possibility of searching not only in colossal Chemical Spaces, but the ability to also comb through spaces of different origins. The number of identical structures in sets from different spaces was found to be extremely low (Lessel et al. 2019) due to the design and setup of the spaces, as well as the diversity of the employed building blocks. No matter how big your in-house library and no matter how many compounds you acquire to add to it, it will only be a tiny fraction of what your chemists are capable of synthesizing. Involving distinct Chemical Spaces increases your chances of finding accessible molecules you would have missed otherwise.
Sometimes the perfect solution is within reach in your own compound library without realization. You can design your own Chemical Space with your accumulated, in-house knowledge and resources. Reactions and building blocks can be defined to create massive numbers of virtual compounds. Multiple big pharma companies built their own, in-house Chemical Spaces to search for scaffold alternatives to reduce costs and time.
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Jan 062023
 

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Description: Adobe Bridge will provide you with centralized access to all the multimedia resources you need for creative projects. Easily edit components in batch, edit RAW digital images, work with IPTC and XMP formats, rate images, add watermarks, and centrally set color settings – Bridge makes your work easier and helps you stay organized.
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Jan 062023
 

Download ZWCAD Mechanical 2023 SP2 x64 full license

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Descriptions of ZWCAD Mechanical 2023 SP2
The program includes 32 options to create construction lines and seven options to create construction circles. Construction lines can be used as references to create other objects and make drafting easier. You can add a centerline to a circle or rectangle by selecting objects. Centerlines can be drawn to one single entity or multiple entities.
Power Dimension makes dimensioning easier with abbreviated dialog boxes that control and expand only the variables relevant to manufacturing and integrate tolerance and fit list information. With Multiple Dimensions, you can create multiple dimensions with minimal input and properly space ordinate, parallel or symmetric items.
Overlapping dimensions can be automatically spaced apart appropriately. It determines the suitable distance from the dimensioned object, making the linear dimensions look neat and clear. Mechanical symbols include surface texture symbols, datum identifiers and targets, taper, center hole, and weld symbols, significantly saving your time and improving your design accuracy.
ZWCAD Mechanical 2023 SP2 Features
Professional Mechanical 2D Sheet Drafting
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Easily generate balloons and BOM
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Enterprise and international standards support
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Mechanical Parts and Generator
Extended Drawing Tools for Manufacturing
Reusable detailing tools
Draw Groove quickly and accurately
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